Enantioselective Henry reaction catalyzed by a novel L-(+)-aspartic acid-derived Schiff base ligand and Cu(II) ion

Authors: GAMZE KOZ, DEMET ASTLEY, STEPHEN THOMAS ASTLEY

Abstract: Mild and efficient enantioselective Henry reactions of nitromethane with various aldehydes were catalyzed by a novel L-(+)-aspartic acid-derived Schiff base ligand in the presence of Cu(II) ions, affording the corresponding adducts in high yields (up to 96%) and enantioselectivities (up to 92% ee).

Keywords: Enantioselective Henry reaction, chiral Schiff base, L-(+)-aspartic acid

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