Pregnane steroids from the heartwood of Azadirachta indica

Authors: BINA SHAHEEN SIDDIQUI, SYED KASHIF ALI, SYED TARIQ ALI, FAYYAZ AHMED

Abstract: The heartwood of Azadirachta indica (Meliaceae) yielded a new steroid (2\alpha, 3\beta, 4\beta-trihydroxypregnan-16-one) and 2 known steroids (2\beta, 3\beta, 4\beta-trihydroxypregnan-16-one and 2\alpha, 3\alpha, 4\beta-trihydroxypregnan-16-one). Their structures were elucidated through spectral studies including 2D NMR (COSY, NOESY, J-resolved, HMQC, HMBC) experiments.

Keywords: Azadirachta indica, Meliaceae, heartwood, steroids, 2\alpha, 3\beta, 4\beta-trihydroxypregnan-16-one, 2\beta, 3\beta, 4\beta -trihydroxypregnan-16-one, 2\alpha, 3\alpha, 4\beta-trihydroxypregnan-16-one.

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