Synthesis, characterization, and biological evaluation of new copper complexes of naphthyl pyrazole ligands

Authors: MELEK HINIS, KULDIP SINGH, DEMET ERDÖNMEZ, AYFER MENTEŞ

Abstract: Two naphthalene pyrazole ligands were synthesized using KOH/DMSO and Cu catalyst and characterized with FT-IR, ESIMS, ¹H, and ¹³C NMR spectroscopies. The crystal structures of 1-(2-methylnaphthalen-1-yl)-1H-pyrazole (MeNap-Pz) ligand have been determined with X-ray crystal structure analysis. Reaction of the ligands with Cu(NO₃)₂x3.5H₂O gave two new complexes and characterized with magnetic susceptibility, molar conductance, FT-IR, LCMS-MS, ICP-OES, NMR, thermogravimetric analysis, and ESR spectra. The spectral data of the ligands are coordinated to the metal ion through the nitrogen atoms of the pyrazole ring. Consequently, it has been determined that [Cu(MeNap-Pz)₂ (NO₃)]NO₃.2H₂O complex showed square planar geometry and [Cu(NapMe-Pz)₂(NO₃)₂].H₂O complex showed octahedral geometry. All compounds were screened for in vitro antibacterial activity and copper complexes have been shown to be effective on bacteria.

Keywords: Naphthyl, pyrazole, copper, antimicrobial activity

Full Text: PDF