Synthesis, Characterization and Genotoxicity of Platinum(II)Complexes With Subtituted Benzimidazole Ligands

Authors: ÖZTEKİN ALGÜL, BERRİN ÖZÇELİK, UFUK ABBASOĞLU, FATMA GÜMÜŞ

Abstract: Five Pt(II) complexes with the ligands 2-ethyl-/ or-benzyl-/ or-phenoxymethyl- and 1-methyl-2-hydroxymethyl- and 1-methyl-2-phenyl- benzimidazoles were synthesized and characterized by elemental analysis, and IR and ^1H-NMR spectra and evaluated for their in vitro genotoxic activities by Rec-Assay test. Based on the data obtained in this study, the Pt(II) complexes tested might be taken into consideration as promising antitumor compounds.

Keywords: Benzimidazol, Platinum(II) complexes, In vitro genotoxic activity, Rec-Assay test

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