Synthesis of novel chiral bisoxazoline ligands with a norbornadiene backbone: use in the copper-catalyzed enantioselective Henry reaction

Authors: RABİA DELİKUŞ, EMİNE ÇAKIR, NADİR DEMİREL, METİN BALCI, BETÜL KARATAŞ

Abstract: Novel chiral bisoxazoline ligands based on norbornadiene were synthesized and used for the asymmetric Henry reaction. Various aromatic aldehydes were converted into chiral $\beta $-nitro alcohols with high yields and moderate to acceptable enantioselectivities under the optimized reaction conditions.

Keywords: Asymmetric synthesis, Henry reaction, chiral bisoxazolines, nitroaldol, copper

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