Bisabolane Type Sesquiterpenes from a Marine Didiscus Sponge

Authors: DENİZ TAŞDEMİR, TIMOTHY S. BUGNI, GINA C. MANGALINDAN, GISELA P. CONCEPCION, MARY KAY HARPER, CHRIS M. IRELAND

Abstract: Two bisabolane type sesquiterpene phenols, (+)-curcuphenol (1) and (+)-curcudiol (2), were isolated from a Philippine marine sponge, Didiscus sp., in addition to \beta -sitosterol (3) and phenethylamine (4). The structures of the metabolites were established on the basis of spectral evidence (1D- and 2D NMR, [\alpha]_{D}, EIMS). (+)-Curcuphenol (1) showed cytotoxicity, which is indicative of a p53 independent mechanism.

Keywords: Marine sponge, Didiscus, (+)-curcuphenol, (+)-curcudiol, \beta -sitosterol, phenethylamine, HCT-116

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