Synthesis, anticandidal activity, and cytotoxicity of some thiazole derivatives with dithiocarbamate side chains

Authors: LEYLA YURTTAŞ, YUSUF ÖZKAY, FATİH DEMİRCİ, GAMZE GÖGER, ŞAFAK ULUSOYLAR YILDIRIM, USAMA ABU MOHSEN, ÖMER ÖZTÜRK, ZAFER ASIM KAPLANCIKLI

Abstract: Some thiazole derivatives bearing dithiocarbamic acid esters were synthesized in order to investigate their anticandidal activity and cytotoxicity. The structures of the obtained final compounds (6a--j) were confirmed by spectral data (IR, ^1H NMR, ^{13}C NMR, and MS) and elemental analysis. The anticandidal activity of the compounds was determined (6a--j) using the microbroth dilution method and their cytotoxicity was evaluated according to the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay against normal cells. Contrary to expectations, weak antifungal activity was observed with IC_{50} values ranging between 30 and 403 \mu g/mL.

Keywords: Thiazole, dithiocarbamate, anticandidal activity, cytotoxicity

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