Some bioactive organotin(IV) derivatives with 3,4-dichlorophenylacetic acid: synthesis, spectroscopic properties, and X-ray structure of [Sn_4(C_4H_9)_8(OOCCH_2C_6H_3Cl_2)_4O_2]

Authors: MUHAMMAD ADEEL SAEED, MUHAMMAD KHAWAR RAUF, . IMTIAZ-UD-DIN, AMIN BADSHAH, MUHAMMAD ZAEEM AKHTAR, BUSHRA MIRZA

Abstract: Some bioactive organotin(IV) derivatives of 3,4-dichlorophenylacetic acid (HL) were synthesized by reacting the ligand acid with various di- or tri-organotin compounds (in suitable mole ratios) in the presence of triethylamine. The structural investigation was carried out via multinuclear (^1H, ^{13}C, and ^{119}Sn) NMR, IR spectroscopy, and X-ray crystallography. The crystal structure of 4 comprises a central Sn_2O_2 core with O atoms bonded to 2 dibutylbis(3,4-dichlorophenylacetato)tin(IV) units. All the Sn atoms of 4 are essentially 5-coordinated in distorted trigonal-bipyramidal geometry. Some of the compounds exhibited significant antibacterial and antifungal activity.

Keywords: Organotin(IV), spectroscopy, distannoxane, X-ray structure, antibacterial, antifungal.

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