Fused Heterocycles: Synthesis of Some New Imidazopyridines as Anti-Mycobacterial Agents

Authors: BİRGÜL ÖZDEN KASIMOĞULLARI, ZAFER CESUR

Abstract: The reaction of semicarbazones bearing an imidazo[1,2-a]pyridine ring system with mercaptoacetic acid was investigated. The anti-mycobacterial activity of the compounds thus obtained were evaluated against Mycobacterium tuberculosis H_{37}Rv, using rifampin as the standard. Only IVe showed activity at 6.25 \mu g mL^{-1}.

Keywords: Imidazo[1,2-a]pyridine, semicarbazones, 4-thiazolidinone, antituberculous activity

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