Effects of Endosulfan on the Isolated Sciatic Nerve of the Frog

Authors: ÜLKÜ ÇÖMELEKOĞLU, BELGİN BÜYÜKAKILLI, AYNUR AVCI ÖZGE

Abstract: The purpose of this study was to investigate the effect of endosulfan on the isolated sciatic nerve of the frog. The nerve was exposed to 0.5 ppm endosulfan for 60 min and then compound action potentials were recorded extracellulary. The latencies, amplitudes, durations of depolarization and repolarization and threshold voltage were measured (n=30). Conduction velocities were calculated using the nerve lengths and latency values of each nerve. It was observed that values of amplitude and duration of repolarization were significantly higher (p<0.05) but threshold voltage was significantly lower (p<0.05) in the exposed group than in the control group.

Keywords: Endosulfan, action potentials, sciatic nerve, nerve conduction

Full Text: PDF