Concentrations of Creatine Kinase and Myocardial Creatine Kinase in Rabbits Constituted Experimental Hyperthyroidism

Authors: İsmail ÇELİK, Mehmet KARA, Eşref YEĞİN, Halis KÖYLÜ

Abstract: In this study, 20 male (1500±50 g) white, New Zealand strain rabbits ( Oryctolagus cuniculus huxley) jere used. Of these ten were used for experimental group, and the others were used controls. To get hyperthyroidism in the experiment animals, L-Thyroxin 50 µg/kg of body weight daily for two weeks, was injected to the animals by intravenous. The control group rabbits were injected only 0.9% isotonic salt water which L-Thyroxin dissolved in it. The levels of total ceratine kinase (CK) and cardirac creatine kinase (CK-MB) were recorded as 1079 ± 597 U/L and 879 ± 128 U/L in control group whereas these parameters were as 3558 ± 1341 U/L and 902 ± 367 U/L in hyperthroidism group, respectively. It was observer that CK (p<0.001) was significantly iincreased whereas the CK-MB was not significantly increased (p<0.05) in hyperthyroidism group. In addition, a significantly correlation was found between CK and Triiodotronin(T 3 ) (r=0.76, p<0.02), and Ck and Thyroxin (T 4 ) (r=0.64, <0.05) in hyperthyroidism group. In conclusion, we agree that routine use of CK measurement to monitor thyroid status may be useful.

Keywords: Hyperthyroidism, CK, CK-MB, rabbit.

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