ABO, Rh Blood Groups and Phosphoglucomutase 1 Enzyme Phenotypes in Individuals With Noninsulin Dependent Diabetes Mellitus

Authors: E. Ferda PERÇİN, İsmihan GÖZE, Ziynet ÇINAR

Abstract: An examination of the relationships between common diseases and polymorphism may facilitate a better understanding of the clinical variability of illnesses and their genetic bases. In this paper, the relationship between blood group and erythrocyte phosphoglucomutase 1 (PGM1) enzyme phenotype and noninsulin-dependent diabetes mellitus (NIDDM) was investigated. The enzyme phenotypes of 205 diabetic individuals were determined using the agglutination method. The results were compared with data from 200 subjects in the control group. When the diabetic individuals and those in the control group were compared according to PGM1 phenotype, no statistically significant difference between the two was observed (p>0.05). However, in ABO and Rh phenotypes the difference was found to be significant (p<0.05). In addition, a rare previously unknown phenotype was discovered. It was determined that this phenotype is the first new phenotype to be identified in the Turkish population. The relationship between this phenotype and diabetes was not statistically significant.

Keywords: Diabetes Mellitus, PGM1, enzyme polymorphism, ABO, Rh.

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