The Histopathologic Effects of Endosulfan on the Mouse Thyroid Gland

Authors: Ayşegül ÇERKEZKAYABEKİR, Tülin AKTAÇ

Abstract: In the present study, the acute toxic effects of endosulfan on thyroid glands were investigated by light and electron microscopy. Endosulfan (LD30 4.16 mg/kg) was injected intraperitoneally into adult male mice. In the light microscopic studes, it was observed that some of the follicles had been damaged and joined together. Furthermore, colloidal fluids had diffused from follicles and dispersed into connective tissues. Swelling in endoplasmic reticulum sacs, expansion in perinuclear area, pycnotic nuclei and accumulation of heterochromatin were determined by electron microscopy.

Keywords: Endosulfan, thyroid, organochlorine insectiside.