Detection of Mutagenic Effects of 2, 4, 5 Tri (Sübstitüe) Phenyl Imidazole and Its Derivatives in Ames/Salmonella/Test System

Authors: AYŞE MERCANGÖZ, BERRİN AYAZ TÜYLÜ

Abstract: The mutagenic effects of 2, 4, 5 tri-phenylimidazole and its nine different derivatives, which are aimed at producing medicine as a primary substance, were investigated by the Ames Salmonella/Microsome plate assay. The test compounds were directly effective, especially in the TA 98 strain. A relationship was found between the mutagenic effect and the positions of the methyl and methoxy groups.

Keywords: Imidazole, 2, 4, 5 triphenyl imidazole, mutagenic activity, Ames/Salmonella/Microsome.

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